Date Added: 20/03/2017

Date Updated: 20/03/2017

Avacopan for ANCA-associated vasculitis – first and subsequent line

Specialties: Orthopaedics, rheumatology & podiatry

Technology Type: Drugs

Stage of development: Experimental - pilot or phase II

Stage of EAA: Prioritised for assessment

Description, patients and keywords:


Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) – first and subsequent line.


Avacopan (CCX-168) is a small molecule, complement C5a receptor inhibitor. Chemoattractant receptors, such as C5aR, are receptors for complement proteins involved in specific inflammatory responses. C5a is believed to be a potent chemoattractant underlying the inflammation-induced damage in certain autoimmune disorders, including AAV, thus inhibitors of C5aR have a therapeutic potential.

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